Spurs have now suffered their worst start to a campaign since 1912 and Ramos will fear for his job at White Hart Lane after seeing his side pick up just two points from their opening seven league games.
After spending nearly £70million on new players during the summer, the Tottenham players have looked well below their best and have been rocked by the departures of Robbie Keane and Dimitar Berbatov.
In contrast, newly promoted Hull City are enjoying every minute of being in the Premier League and are writing a fairytale story of their own following their memorable 2-1 win over Arsenal just a week ago.
You could sense the anxiety among the home supporters from the start of the game, but it could have been a different story if Gareth Bale had broken the deadlock within the opening 60 seconds.
The Welsh defender broke clear in the box and saw his shot cleared off the line by Hull defender Andy Dawson.
Hull had a golden chance to open the scoring on three minutes. Daniel Cousin played the ball into Geovanni who cut inside Jonathan Woodgate and with just Heurelho Gomes to beat he fired the ball over the bar.
This was never going to be a dull affair and Tottenham came close again 60 seconds later when Aaron Lennon cross caused all kinds of problems for the Hull defence.
The ball eventually broke free to Roman Pavlyuchenko, who directed his shot straight at Hull keeper Boaz Myhill.
There must be something in the north London air which makes Hull play at their best and, in particular, Geovanni.
No-one will forget his stunning strike against Arsenal last week and the Brazilian midfielder tried to match that with another spectacular goal on seven minutes when he fired an unstoppable right-foot free-kick which sailed past Gomes into the top left-hand corner.
Tottenham tried everything to get themselves back into the game. Jermaine Jenas played a quick free-kick into the path of Fraizer Campbell on 15 minutes who drilled his shot just past the post.
Bale then fired a 30-yard free-kick on 21 minutes which produced a stunning save from Myhill who tipped the ball onto the bar.
Ramos must have been praying this was the day when his new signings were finally going to show their potential, but the misery just continued for Pavlyuchenko who was forced to leave the field through injury on 34 minutes.
Hull should have doubled their lead on 36 minutes when George Boateng laid the ball in to Dean Marney, who fired a superb shot on the turn, but saw his effort cannon back off the post with Gomes well and truly beaten.
Tottenham also hit the woodwork on 42 minutes. Lennon played the ball back for Woodgate, whose shot deflected off Michael Turner and came back off the post.
Ramos must have said some strong words to his players at the half-time interval as they looked far more energetic in the second half.
Substitute Darren Bent was determined to make an impact and came within a whisker of putting his side back on level terms on 57 minutes.
Luka Modric played a high ball over the top of the Hull defence. Bent reacted the quickest and lifted the ball over Myhill, but his shot went inches past the post.
Hull should have put the game beyond Tottenham on 73 minutes when Marlon King broke clear of the defence, but saw his shot kept out by the legs of Gomes, but Phil Brown's side held on to help them go third in the Premier League.