Samir Nasri and Marouane Chamakh had put the Gunners in complete control but Spurs - who had just one Premier League away victory over their old rivals, in May 1993 - regrouped for the second half following the introduction of fit-again England striker Jermain Defoe.
Gareth Bale pulled a goal back on 50 minutes, before an inexplicable handball from captain Cesc Fabregas from a free-kick gave away a penalty which Rafael van der Vaart converted.
Arsenal were then condemned to successive home league defeats for the first time in 13 years when Younes Kaboul headed in a dramatic late winner.
Source: PA
Source: PA