Civil unrest in and around Tottenham began last weekend and quickly spread to other areas of the capital and other major cities across England.
Scudamore confirmed the game at White Hart Lane would not be played but was "positive" that the other nine fixtures in the opening round of top-flight games would go ahead.
He said: "The very latest situation is that Tottenham and Everton has gone. The police have done a fantastic job, but it's been a crime scene all week and the council have not had enough time to do what they need.
"The other nine fixtures are looking positive, subject to any more trouble.
"At 6pm tonight we will have a very clear picture. The Tottenham game is a real shame but we support the police in what they are doing.
"They want these games to go on as much as we do."
Source: PA
Source: PA