A neck injury resulted in Keane missing the opening two games of Tottenham's training camp in France last month.
Spurs maintained a 100% record over three games, have also beaten Inter Milan at home, and drawn 1-1 at Borussia Dortmund.
"The types of teams we have played (in pre-season) have been good European teams. We've dealt well with the different styles of play and it was a good learning experience for us," said club captain Ledley King, who also misses the game against Real Sociedad at White Hart Lane this afternoon, kick-off 3pm.