The result of the match had been determined by half-time after Fulham had raced into a four-goal advantage by the break.
Danny Murphy scored from the spot 11 minutes in after Alan Hutton barged down Clint Dempsey in the box.
The Cottagers captain, who signed a new deal with the club on Friday, added a second penalty three minutes later after Michael Dawson was sent off for tugging back Moussa Dembele in the box.
Brede Hangeland stabbed home to make it 3-0 before Dembele rifled home a blistering strike just before half-time to seal the impressive win.
The win will provide another morale boost for Mark Hughes' resurgent side but will raise serious questions about Tottenham's ability to challenge for honours, particularly given that Harry Redknapp fielded arguably his strongest team available.
Source: PA
Source: PA