The club confirmed on Wednesday morning that the Croatia international underwent surgery on Tuesday night, meaning he could now miss the Champions League last-16 first leg at AC Milan on February 15.
He will also sit out the Barclays Premier League game at Blackburn and will be unavailable for Saturday's home clash with Bolton and the following weekend's trip to Sunderland.
Tottenham said in a statement: "Luka Modric has undergone surgery to remove his appendix.
"The Croatia midfielder was diagnosed with acute appendicitis after contacting our medical staff complaining of abdominal discomfort. He is likely to be sidelined for around two weeks."
Source: PA
Source: PA