Both Spurs and Villa are battling for fourth in the Barclays Premier League and the game at White Hart Lane could prove vital in the final shake-up.
"That's a big game for us, a massive game," said Defoe.
"Villa are a good side, they've got a great manager and they're playing well.
"But the way we're playing we're confident going into every game."
Source: PA
Source: PA