Defoe netted his first and second Premier League goals of the campaign during Sunday's thrilling 3-3 draw with Wolves at Molineux. It took his top flight tally to 99 - the same number as he has managed in all competitions for Spurs.
Both goals came from stunning strikes from the edge of the box, but a late header from Wolves substitute Steven Fletcher denied Spurs the victory that would have seen them climb back into fourth spot.
Defoe has been frustrated by his lack of goals in a stop-start campaign but now wants to help Spurs to finish off AC Milan after their 1-0 first leg triumph.
He said: "If I score my 100th goal for Tottenham on Wednesday night there will be a reason why. I say that because I always believe things happen for reason but it would be nice to do it. It's been a long while since I scored my last Premier League goal. More than anything, it has been frustrating.
"As a forward when you are scoring goals, you are full of confidence and buzzing about. When you are not scoring your game changes, you start snatching at things or take an extra touch because you want to be so precise. But I've always tried to get into the right positions to score and I'll never stop doing that and it was good to get the two at Wolves."
Source: PA
Source: PA