The Spurs striker sustained an ankle injury and was stretchered off in England's 3-1 Euro 2012 qualifying victory over Switzerland on Tuesday night.
However, Defoe is confident he will be fit in time for Spurs' game against West Brom at the Hawthorns on Saturday.
"I jarred my ankle or my knee but it feels alright," he has said.
"I've always said I'll do my best to make sure I'm out there.
"I've just got to rest it (the injury). I'll just keep icing it and I'm sure I'll be ok."
Defoe was satisfied with England's performance in Switzerland as they followed up Friday's 4-0 triumph over Bulgaria at Wembley.
"I think the movement in the first half was maybe better than the previous game," he added. "We did really well, the manager was really happy.
"The energy again was good. In the second half they blew up a bit in the first ten minutes but overall I think we were the better side."