Clemence has been back in full training since the start of October and will now get his first run-out of the season at Dagenham & Redbridge's Victoria Road home when Spurs second string take on The Hammers.
Spurs reserves boss Colin Calderwood said: "Steve will be involved for the first time this season.
"He's completed a fortnight's training with the rest of the first team and he'll play for a period of the game and hopefully come through okay.
"Steve's been a Trojan in the gym. You just have your fingers crossed he can now have a sustained period of football," he told the club's official website.
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