Despite a win ratio better than any other Spurs boss in the Premier League era, the Portuguese has paid for his side sitting seventh in the league after 16 matches this term, following a summer spend of over £100million on new talent
As such, thoughts have immediately turned to the men who are most likely to replace Villas-Boas, as Spurs chairman Daniel Levy looks for his side to claim a top-four place.
Immediately in as 6-4 favourite for the role is former England boss Fabio Capello, currently manager of Russia .
Aside from the Italian, there are a number of others also in the frame, and here's a look at the top 10 contenders to take the White Hart Lane hotseat:
Most of the White Hart Lane faithful had lost faith with Villas-Boas after the club spent £107 million on new players in the summer, although Villas-Boas hinted that the new signings weren't chosen by him. Chairman Daniel Levy and Director of Football Franco Baldini have the final say on transfer dealings and any new manager will have to get used to their influence.
Capello was at White Hart Lane during the 5-0 defeat to Liverpool on Sunday and he has close connections with Baldini, who was Capello's assistant during their time in charge of the England national team. The Italian manager has enjoyed great success all over the world but the one stumbling block to him taking over at Tottenham would be the fact he is currently in charge of Russia, who are due to play at the 2014 World Cup next summer.
Jurgen Klinsmann is USA national team manager who has been linked with the job, but again will not be free till next season. The former Spurs striker is a hugely popular figure amongst Tottenham fans but it remains to be seen if he can be tempted away from his California home. Meanwhile, Guus Hiddink appeared to rule himself out of the running as the 14/1 chance is reportedly due to take over as Holland manager after the World Cup.
If Tottenham wanted to wait to appoint someone like Capello or Klinsmann after next year's World Cup, they may consider appointing someone on an interim basis in the meantime. Tim Sherwood would appear to fit that bracket as the former Spurs midfielder, and current Tottenham youth coach, is keen to move into management . Glenn Hoddle could also be viewed as something of a short-term fix as the former Tottenham midfielder looks for his first managerial job since leaving Wolves in 2006. Hoddle was manager of Tottenham from 2001 to 2003 .
Meanwhile, several up-and-coming managers have been linked with the role. Martin Laudrup, the Dane's fluid, passing style of football has attracted plenty of admirers during his time as Swansea manager and it is open to debate whether he thinks he has taken the Welsh club as far as he can after they won the Capital One Cup last season.
Mauricio Pochettino has also impressed after less than a year in charge at Southampton. Since he joined the club in January, the Argentine has turned Saints into a force to be reckoned with in the Premier League and it is only a matter of time before so called 'bigger clubs' come calling.
Ajax boss Frank de Boer and Basle's Murat Yakin, are both accomplished and successful. Luis Enrique, is a Spanish retired footballer, and the current manager of La Liga club Celta de Vigo. Rudi Garcia (born 20 February 1964) is a French football manager and former midfielder. He is currently the manager of Italian Serie A club Roma. Certainly the Italian Baldini will influence the appointment of the next manager.
Lord Alan Sugar was baffled by Andre Villas-Boas’ tactics at Tottenham and admits he is dreaming of Sir Alex Ferguson taking over the reins at White Hart Lane.
Come on You Spurs